IP03: Multi-species Ontologies of the Craniofacial Musculoskeletal System
Title | IP03: Multi-species Ontologies of the Craniofacial Musculoskeletal System |
Publication Type | Conference Paper |
Year of Publication | 2016 |
Authors | Mejino JL, Brinkley J, Cox T, Detwiler L |
Conference Name | International Conference on Biomedical Ontology and BioCreative (ICBO BioCreative 2016) |
Date Published | 11/30/16 |
Publisher | CEUR-ws.org Volume 1747 |
Other Numbers | Vol-1747|urn:nbn:de:0074-1747-1 |
Abstract | We created the Ontology of Craniofacial Development and Malformation (OCDM) [1] to provide a unifying framework for organizing and integrating craniofacial data ranging from genes to clinical phenotypes from multi-species. Within this framework we focused on spatio-structural representation of anatomical entities related to craniofacial development and malformation, such as craniosynostosis and midface hypoplasia. Animal models are used to support human studies and so we built multi-species ontologies that would allow for cross-species correlation of anatomical information. For this purpose we first developed and enhanced the craniofacial component of the human musculoskeletal system in the Foundational Model of Anatomy Ontology (FMA)[2], and then imported this component, which we call the Craniofacial Human Ontology (CHO), into the OCDM. The CHO was then used as a template to create the anatomy for the mouse, the Craniofacial Mouse Ontology (CMO) as well as for the zebrafish, the Craniofacial Zebrafish Ontology (CZO). |
URL | http://ceur-ws.org/Vol-1747/IP03_ICBO2016.pdf |