IT401: An analysis of differences in biological pathway resources
Title | IT401: An analysis of differences in biological pathway resources |
Publication Type | Conference Paper |
Year of Publication | 2016 |
Authors | Wang L, Gennari J, Abernethy N |
Conference Name | International Conference on Biomedical Ontology and BioCreative (ICBO BioCreative 2016) |
Date Published | 11/30/16 |
Publisher | CEUR-ws.org Volume 1747 |
Other Numbers | Vol-1747|urn:nbn:de:0074-1747-1 |
Abstract | Integratingcontentfrommultiplebiologicalpathwayresourcesisnecessarytofullyexploitpathwayknowledgefortheofbiologyandmedicine.Dif-ferencesincontent,representation,coverage,andmoreoccurbetweendatabases,andarechallengestoresourcemerging.Weintroduceatypologyofrepresentationaldifferencesbetweenpathwayresourcesandgiveexam-plesusingseveraldatabases:BioCyc,KEGG,PANTHERpathways,andReactome.WealsodetectandquantifyannotationmismatchesbetweenHumanCycandReactome.Thetypologyofmismatchescanbeusedtoguideentityandrelationshipalignmentbetweenthesedatabases,helpingusidentifyandunderstandinourknowledge,andallowingtheresearchcommunitytoderivegreaterfromtheexistingpathwaydata. |
URL | http://ceur-ws.org/Vol-1747/IT401_ICBO2016.pdf |