BT204: CancerMine: Knowledge base construction for personalised cancer treatment
Title | BT204: CancerMine: Knowledge base construction for personalised cancer treatment |
Publication Type | Conference Paper |
Year of Publication | 2016 |
Authors | Lever J, Jones M, Jones SJm |
Conference Name | International Conference on Biomedical Ontology and BioCreative (ICBO BioCreative 2016) |
Date Published | 11/30/16 |
Publisher | CEUR-ws.org Volume 1747 |
Other Numbers | Vol-1747|urn:nbn:de:0074-1747-1 |
Abstract | Knowledge of the relevant genomic aberrations that drive a particular cancer type is necessary to accelerate efficient interpretation of genomic data and enable large-scale endeavors in precision medicine. Currently, this field is limited by the lack of focused and scalable literature curation tools that can reliably capture the required information. Here we present a knowledge-base of genes that have been described in the literature as drivers, oncogenes or tumour suppressors with respect to a specific type of cancer. We have annotated a large body of literature which reports oncogenic aberrations using a custom designed annotation tool. We then applied VERSE, an in-house relation extraction tool, to catalogue driver mutations and illustrate the ability to build a useful resource for clinical interpretation of genomic data for personalized treatment approaches. |
URL | http://ceur-ws.org/Vol-1747/BT204_ICBO2016.pdf |