IP34: Plant Reactome: A Resource for Comparative Plant Pathway Analysis

TitleIP34: Plant Reactome: A Resource for Comparative Plant Pathway Analysis
Publication TypeConference Paper
Year of Publication2016
AuthorsNaithani S, Preece J, Gupta P, D’Eustachio P, Elser J, Mundao A, Weiser J, McKay S, Stein L, Ware D, Jaiswal P
Conference NameICBO and BioCreative 2016
Date Published11/30/16
PublisherCEUR-ws.org Volume 1747
Conference LocationCorvallis, OR
Other NumbersVol-1747|urn:nbn:de:0074-1747-1

The Plant Reactome database (http://plantreactome.gramene.org/) hosts metabolic, genetic and signaling pathways for several model and crop plant species. The Reactome data model organizes gene products, small molecules and macromolecular interactions into reactions and pathways in the context of their subcellular location to build a systemslevel framework of a plant cell. The Plant Reactome features Oryza sativa (rice) as a reference species, built by importing the RiceCyc metabolic network and curating new metabolic, signaling and genetic pathways. The Plant Reactome database now contains 241 rice reference pathways and orthology-based pathway projections for 58 plant species. Plant Reactome allows users to i) compare pathways across various plant species; ii) query and visualize curated baseline and differential expression data available in the EMBL-EBI’s Expression Atlas in the context of pathways in the Plant Reactome; and iii) analyze genome-scale expression data and conduct pathway enrichment analysis to enable researchers to identify pathways affected by the stresses or treatments studied in their data sets. Plant Reactome links out to numerous external reference resources, including the gene pages of Gramene, Phytozome, SoyBase, Legume Information System, PeanutBase, Uniprot, as well as ChEBI for small molecules, PubMed for literature supported evidences, and GO for molecular function and biological processes. Users can access/download our data in various formats from our website and via APIs. The presentation will discuss tools for pathway enrichment analysis and homologue pathway comparison, development of the Plant Reactome portal, curation of reference rice pathways, and phylogeny-based analyses of projected pathway annotations. The project is supported by the Gramene database award (NSF IOS-1127112)and the Human Reactome award (NIH: P41 HG003751, ENFIN LSHG-CT-2005-518254, Ontario Research Fund, and EBI Industry Programme).